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Synthesis of new ethylenediamine-platinum(II) complexes starting from amino acids and their antitumor activity

Brunner, Henri ; Kroiss, Reinhard ; Schmidt, Manfred ; Schönenberger, Helmut



Abstract

Amino acids, obtained by azlactone or hydantoin synthesis were converted to ethylenediamines RCH2CH(NH2)CH2NH2 via esters, amides, and LiAlH4 redn. Pt complexes I were prepd. from these diamines and tested for antitumor activity with the hormone independent human mammary carcinoma cell line MDA-MB 231 along with I complexes with Cl ligands replaced by a series of monodentate and bidentate anions. ...

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