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(1-Benzylethylenediamine) platinum(II) complexes as antitumor agents

Brunner, Henri ; Schönenberger, Helmut ; Schmidt, Manfred ; Holzinger, Ulrich ; Unger, Gerfried ; Engel, Juergen


The title compds. I [R1-4 = H, C1-6 alkyl, PhCH2, phenylethyl; R5 = thienyl, indolyl, imidazolyl, (substituted) Ph; X = pharmaceutically acceptable anion], useful as antitumor agents, are prepd. by complexation of II by Pt compds. Thus, 1 mmol K2PtCl4 in H2O was treated with 1 mmol II (R1-4 = H, R5 = Ph) at 50 Deg and pH 6 in a flask protected from light to give I (R1-4 = H, R5 = Ph, X = Cl) ...


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