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Effect of estrophilic platinum complex on the mouse uterus

Amselgruber, W. ; Sinowatz, F. ; Spruss, Thilo ; Schneider, M. R. ; Karl, J. ; Schönenberger, Helmut



Abstract

The effects of a newly synthesized estrogen-receptor affine platinum complex [dichloro-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine-platinum(II), mesoconfiguration] on the mouse uterus were studied using light and electron-microscopy. The results were compared with Tamoxifen, cisplatin and the estrophilic ligand [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine-dihydrochloride, ...

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