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Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199

Trebert-Haeberlin, S. ; Lux, F. ; Karl, J. ; Spruss, Thilo ; Schönenberger, Helmut


As part of an examn. of the cytostatic effects of 1,2-diarylethylenediamine-platinum(II)-complexes the contents of Pl and biol. essential trace elements of tumor tissue and different organs were detd. by neutron activation anal. The activation anal. procedure, sepn. of 32P, and isolation of 199Au and 99Mo are described.

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