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Zusammenfassung
4-HOC6H4N(CHMeCF3)COC6H4OH-4 (I) was prepd. by reaction of 4-MeOC6H4N:PPh3 with MeCOCF3, followed by redn., acylation with 4-MeOC6H4COCl, and demethylation. I had a relative binding affinity for the estradiol receptor of 2.4, cf. estradiol 100. It had no atitumor activity agonist hormone-dependent mammary tumors.
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