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Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma

Karl, Johann ; Gust, Ronald ; Spruss, Thilo ; Schneider, Martin R. ; Schönenberger, Helmut ; Engel, Juergen ; Wrobel, Karl Heinz ; Lux, Franz ; Trebert-Haeberlin, Susanne



Abstract

[1,2-Bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes with one substituent in the 2-position (Me, CF3, F, Cl, Br, I: meso- and dl-1-PtCl2, meso-(3-5)-PtCl2, meso-(7 and 8)-PtCl2) or 2 substituents in the 2,6-positions (Me, Cl: meso-2-PtCl2, meso- and dl-6-PtCl2) in both benzene rings were synthesized and tested for estrogenic and cytotoxic activities. Two complexes possessed ...

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