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Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex

Schneider, M. R. ; Spruss, Thilo ; Schiller, C. D. ; Humm, A. ; Schönenberger, Helmut


In rats, the Pt complex I inhibited prostate and mammary gland hormone-dependent tumors, but had no effect on any of the hormone-independent tumors tested. The prostatic tumor-inhibiting activity of I was better than that of the related ligand without Pt. The endocrine effects of I on accessory sex organ wt. and testosterone levels were only slightly less than those of the potent estrogen ...


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