Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Inorganica chimica acta | ||||
Verlag: | Elsevier | ||||
Band: | 156 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 2 | ||||
Seitenbereich: | S. 291-301 | ||||
Datum: | 1989 | ||||
Zusätzliche Informationen (Öffentlich): | CAN 111:16657 78-7 Inorganic Chemicals and Reactions 6505-37-9 (2,6-Dichloro-3-methoxybenzaldehyde); 19447-00-8 (2,6-Dimethyl-4-methoxybenzaldehyde); 53039-48-8; 61000-21-3 (2,6-Dimethyl-4-methoxybenzyl alcohol); 121020-64-2 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, in prepn. of pyridylmethylamine ligands); 100-70-9 (2-Cyanopyridine) Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, pyridylmethylamine ligands by); 10294-33-4 (Boron tribromide); 10294-34-5 (Boron trichloride) Role: RCT (Reactant), RACT (Reactant or reagent) (deprotection by, of methoxy derivs. of pyridylmethylamines); 121131-35-9P; 121131-36-0P; 121131-37-1P; 121131-38-2P; 121131-39-3P; 121131-42-8P; 121131-43-9P; 121131-44-0P; 121131-45-1P; 121131-46-2P; 121131-47-3P; 121131-48-4P; 121131-49-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of racemic, against hormone-dependent mammary carcinoma); 121131-40-6P; 121131-41-7P Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of, against hormone-dependent mammary carcinoma); 58088-48-5P; 121020-52-8P; 121020-53-9P; 121020-54-0P; 121020-55-1P; 121020-56-2P; 121020-57-3P; 121020-58-4P; 121020-59-5P; 121020-60-8P; 121020-61-9P; 121020-62-0P; 121020-63-1P; 121037-14-7P; 121037-15-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and deprotection of); 91-02-1P; 6305-18-6P; 27049-45-2P; 121020-34-6P; 121020-35-7P; 121020-36-8P; 121020-37-9P; 121020-38-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with hydroxylamine hydrochloride, pyridylmethylamine ligand by); 1826-28-4P; 2116-73-6P; 58088-15-6P; 121020-39-1P; 121020-40-4P; 121020-41-5P; 121020-42-6P; 121020-43-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, by zinc, pyridylmethylamine ligand by); 121020-44-8P; 121020-45-9P; 121020-46-0P; 121020-47-1P; 121020-48-2P; 121020-49-3P; 121020-50-6P; 121037-13-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, pyridylmethylamine deriv. by); 121020-19-7P; 121020-20-0P; 121020-21-1P; 121020-22-2P; 121020-23-3P; 121020-24-4P; 121020-25-5P; 121020-26-6P; 121020-27-7P; 121020-28-8P; 121020-29-9P; 121020-30-2P; 121020-31-3P; 121020-32-4P; 121020-33-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 2746-25-0; 61000-22-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with pyridyltrimethylsiloxyacetonitrile in prepn. of pyridylmethylamines); 71189-77-0 (2-Pyridyltrimethylsiloxyacetonitrile) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with benzyl bromides in prepn. of pyridylmethylamines); 5470-11-1 (Hydroxylamine hydrochloride) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridyl ketones followed by redn. in prepn. of pyridylmethylamine ligands); 83-38-5; 123-11-5; 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridylmethylamines); 7440-66-6 (Zinc) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethyl oximes in prepn. of pyridylmethylamine derivs.); 16853-85-3 (Lithium aluminum hydride); 16940-66-2 (Sodium tetrahydroborate) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethylimines) | ||||
Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
Projekte: | SFB 234 | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | Neoplasm inhibitors (lymphocytic leukemia, platinum complexes with pyridylmethylamines) Neoplasm inhibitors (mammary gland carcinoma, platinum complexes with pyridylmethylamines) cytotoxicity platinum pyridylmethylamine complex aminepyridylmethyl platinum complex | ||||
Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 17672 |
Zusammenfassung
Fifteen ligands of the pyridylmethylamine type and their PtCl2 complexes were prepd., characterized and subjected to a screening system for evaluation of a specific activity against the hormone-dependent mammary carcinoma. To test the estrogenic activity of the ligands, the relative binding affinity (RBA, in vitro) and the uterotrophic and antiuterotrophic activities (mouse uterine wt. test, in ...
Zusammenfassung
Fifteen ligands of the pyridylmethylamine type and their PtCl2 complexes were prepd., characterized and subjected to a screening system for evaluation of a specific activity against the hormone-dependent mammary carcinoma. To test the estrogenic activity of the ligands, the relative binding affinity (RBA, in vitro) and the uterotrophic and antiuterotrophic activities (mouse uterine wt. test, in vivo) were detd. To study the cytotoxic effects, the PtCl2 complexes were tested in vitro towards the hormone-independent human mammary carcinoma cell line MDA-MB 231 and in vivo towards the lymphocytic P388 leukemia. Finally, there was a comparative test of ligands and PtCl2 complexes in the hormone-independent MXT (3.2) Ovex mammary carcinoma and the hormone-dependent MXT M3.2 mammary carcinoma.
Metadaten zuletzt geändert: 24 Mai 2018 12:18