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Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Part I. Synthesis

Jennerwein, Margaretha, Gust, Ronald, Müller, Richard, Schönenberger, Helmut, Engel, Juergen, Berger, Martin R., Schmaehl, Dietrich, Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Part I. Synthesis. Archiv der Pharmazie 322 (1), pp. 25-29.

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Abstract

The prepn. of stereoisomeric 1,2-bis(3-hydroxyphenyl)ethylenediamines (L) from meso-1,2-bis(2-hydroxyphenyl)ethylenediamine and 3-methoxybenzaldehyde by a diaza-Cope-rearrangement and subsequent ether cleavage with BBr3 and their conversion to PtLCl2 with K2PtCl4 are described. PtLCl2 were characterized by CD, IR and NMR spectra.


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Item type:Article
Date:1989
Additional Information (public):CAN 110:224375 78-7 Inorganic Chemicals and Reactions 591-31-1 (3-Methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reaction of, with diphenylethylenediamines followed by diaza-Cope rearrangement and ether cleavage by boron tribromide); 58519-80-5 (meso-1,2-Bis(2-hydroxyphenyl)ethylenediamine) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reaction of, with methoxybenzaldehyde followed by diaza Cope rearrangement and ether cleavage); 119386-71-9P Role: RCT (Reactant), PREP (Preparation), RACT (Reactant or reagent) (formation and reaction of, with methoxybenzaldehyde followed by diaza-Cope rearrangement and ether cleavage by boron tribromide); 119386-70-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage by boron tribromide and resoln. of, by tartaric acid); 93913-16-7P; 119435-17-5P; 120665-17-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage of, by boron tribromide); 119386-69-5P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrolysis of, followed by cleavage reaction with boron tribromide); 93856-31-6P; 93913-25-8P; 93983-45-0P; 119386-68-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and proton NMR of); 119435-15-3P; 119435-16-4P; 119479-53-7P; 119479-54-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with bis(hydroxyphenyl)ethylenediamine stereoisomers)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1989:224375Other
Keywords:Isomerism and Isomers (stereo-, of bis(3-hydroxyphenyl)ethylenediamine and their platinum complexes) hydroxyphenylethylenediamine stereoisomer platinum hydroxyphenylethylenediamine stereoisomer amine hydroxyphenylethylenedi platinum stereoisomer
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17673
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