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Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and antitumor and estrogenic properties

Gust, Ronald ; Burgemeister, Thomas ; Mannschreck, Albrecht ; Schönenberger, Helmut


Erythro- and threo-configurated PtL(H2O)(SO4) (L = 2,6-Cl2-4-HOC6H2CH2NH2CH2NH2R; R = Ph, 4-FC6H4, 3-HOC6H4, 4-HOC6H4, 2,6-F2C6H3, 2,6-Cl2C6H3, 2-F-4-HOC6H3, 2-Cl-4-HOC6H3) were synthesized and tested for estrogenic and antitumor activities. The ligands were obtained by a 3-step reaction. The stilbenes were reacted with a mixt. of ICl and NaN3 to yield the resp. 1,2-diazido-1,2-diphenylethanes. ...


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