Hartmann, Rolf W., Vom Orde, Hans Dieter and Schönenberger, Helmut (1990) Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: influence of hydrophobic groups substituted in the ortho position of the benzamide fragment on activity. Archiv der Pharmazie 323 (2), pp. 73-78.
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Abstract
Title compds. I (R = R2 = H; R1 = Me, F, Cl, Br, CF3; R = H, R1 = R2 = Cl) were prepd. by acylating 4-MeOC6H4NMeCF3 with 2,6,4-R1R2(MeO)C6H2COCl (II) to give I (R = Me) and demethylating. II were obtained from 2,6,4-R1R2(MeO)C6H2Ac by NaOBr oxidn. I (R = R2 = H, R1 = Me, F) had true antiestrogenic activity and I (R = R2 = H, R1 = Cl) was a strong inhibitor of murine hormone-dependent mammary carcinoma.
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 1990 | ||||
| Additional Information (public): | CAN 113:23304 25-19 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 117730-46-8 Role: RCT (Reactant), RACT (Reactant or reagent) (acylation of); 400-72-6 Role: RCT (Reactant), RACT (Reactant or reagent) (carboxylation of); 24826-74-2; 41068-36-4; 74457-86-6; 86111-47-9; 89691-67-8 Role: RCT (Reactant), RACT (Reactant or reagent) (oxidn. of); 127817-93-0P; 127817-94-1P; 127817-95-2P; 127817-96-3P; 127817-97-4P; 127851-72-3P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and antiestrogenic and antitumor activity of); 394-42-3P; 6245-57-4P; 21971-21-1P; 74317-85-4P; 94278-69-0P; 127817-85-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and chlorination of); 127817-87-2P; 127817-88-3P; 127817-89-4P; 127817-90-7P; 127817-91-8P; 127817-92-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and demethylation of); 321-24-4P; 31310-08-4P; 50424-99-2P; 88741-40-6P; 98187-17-8P; 127817-86-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with trifluoropropylaniline) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Projects: | SFB 234 | ||||
| Identification Number: |
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| Keywords: | Neoplasm inhibitors ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides) Uterus ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides effect on) Estrogens Role: RCT (Reactant), RACT (Reactant or reagent) (antagonists, (hydroxyphenyl)(trifluoropropyl)hydroxybenzamides as) hydroxyphenylbenzamide prepn antiestrogenic antitumor uterus hydroxyphenylbenzamide prepn | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17682 |
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