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Zusammenfassung
The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was obsd. Combinations with established cytostatic agents like platinum complexes or other antitumor compds. also yielded partly additive effects. In ...
Zusammenfassung
The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was obsd. Combinations with established cytostatic agents like platinum complexes or other antitumor compds. also yielded partly additive effects. In expts. performed with asparaginase, L-aspartic acid-beta -hydroxamate gave synergistic growth inhibition of P388 D1 cells in vitro, which was reflected by additive effects against murine leukemia P388 in vivo.