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1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation

Schwarz, Walter ; Hartmann, Rolf W. ; Schönenberger, Helmut


Z-1-(4-Hydroxyphenyl)-1-(4- or 3-pyridyl)-2-phenylbut-1-enes and their acetates are weak estrogens (uterine wt. test, immature mouse), which cause a marked tumor growth inhibition on the hormone-dependent MXT mammary carcinoma of the mouse. Slight estrogenic side effects detd. by uterine wt. were detectable in this tumor expt.

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