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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Inorganica chimica acta | ||||
| Verlag: | Elsevier | ||||
| Band: | 195 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
| Seitenbereich: | S. 77-87 | ||||
| Datum: | 1992 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 117:203879 78-7 Inorganic Chemicals and Reactions 143988-12-9P Role: PREP (Preparation) (formation of racemic, from bis(fluorophenyl)ethylenediamine sulfato complex in DMSO); 125948-92-7P Role: PREP (Preparation) (formation of racemic, from bis(fluorophenyl)ethylenediamine sulfato complex in aq. soln.); 143988-11-8P; 143989-42-8P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(fluorophenyl)ethylenediamine sulfato complex in DMSO); 61951-01-7P; 62048-57-1P; 143989-39-3P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(fluorophenyl)ethylenediamine sulfato complex in aq. soln.); 143989-43-9P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(fluorophenyl)ethylenediamine sulfopropionato complex in soln.); 143988-09-4P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfato complex and chloride); 138258-84-1P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfato or sulfopropionato complex and chloride); 143989-46-2P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfopropionato complex and chloride); 143989-44-0P; 143989-45-1P; 144012-63-5P; 144012-64-6P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfopropionato complex in soln.); 143982-84-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and complexation of, with platinum arylethylenediamine complexes); 143989-38-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with sulfopropionate); 143989-40-6P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and soln. chem. and antitumor activity of racemic); 143989-39-3P; 143989-44-0P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and soln. chem. and reaction with chloride and antitumor activity of); 125949-84-0 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of racemic, with sulfopropionate); 5961-88-6 (3-Sulfopropionic acid anhydride) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with barium carbonate and silver sulfate); 14708-56-6 (Dipotassium tetraiodoplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with bis(hydroxyphenyl)ethylenediamine); 10294-26-5 (Disilver sulfate) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with sulfopropionic acid anhydride-barium carbonate rx product); 143989-41-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (soln. chem. and antitumor activity of racemic) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
| Sonstige Projekte: | SFB 234 | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Neoplasm inhibitors (mammary gland carcinoma, platinum sulfato or sulfopropionato complexes with diarylethylenediamines) Mammary gland (neoplasm, carcinoma, inhibitors, platinum sulfato or sulfopropionato complexes with diarylethylenediamines) antitumor agent platinum ethylenediamine sulfopropionato sulfato | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 17694 |
Zusammenfassung
The syntheses, solid state and soln. chem., and the in vitro cytotoxic activities of H2O sol. (1,2-diaryl-1,2-ethylenediamine)platinum(II) complexes, having either the sulfato or the novel sulfopropionato anionic leaving group, are described. The compds. were prepd. by allowing the (1,2-diaryl-1,2-ethylenediamine)diiodoplatinum(II) complexes and either Ag2SO4 or Ag sulfopropionate to react in ...
Zusammenfassung
The syntheses, solid state and soln. chem., and the in vitro cytotoxic activities of H2O sol. (1,2-diaryl-1,2-ethylenediamine)platinum(II) complexes, having either the sulfato or the novel sulfopropionato anionic leaving group, are described. The compds. were prepd. by allowing the (1,2-diaryl-1,2-ethylenediamine)diiodoplatinum(II) complexes and either Ag2SO4 or Ag sulfopropionate to react in H2O. IR studies of the complexes in the solid state indicate that the prepn. are mixts. of Pt species, whereby the anionic leaving groups show varying forms of Pt coordination. These compns. vary depending on the procedure used to isolate the Pt complexes. The aq. soln. chem. was studied by a reversed-phase HPLC assay. The results of these studies show several Pt species in soln. From the column retention properties of the species and their behavior to changes in pH, these soln. components are various monomers and oligomers of the parent Pt complex. These results are in agreement with previous 195Pt and 15N NMR studies from other diaminePt(II) complexes. The type of arom. substitution has an influence on the qual. compn. of the aq. Pt species; an addnl. Pt species is obsd. in aq. solns. of Pt complexes possessing an ortho phenol group compared to the complexes possessing a para F group. Aq. reactions of the Pt complexes with Cl- indicate that the sulfopropionato ligand is more stable-bound than the SO42- ligand; results from cell culture cytotoxicity tests show little difference between the cytotoxic activities of the complexes possessing a sulfato or a sulfopropionato leaving group.
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