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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | European journal of medicinal chemistry | ||||
| Verlag: | Elsevier | ||||
| Band: | 28 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 2 | ||||
| Seitenbereich: | S. 103-115 | ||||
| Datum: | 1993 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 120:44392 78-7 Inorganic Chemicals and Reactions 100-83-4 (3-Hydroxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (chlorination of); 14708-56-6 (Dipotassium tetraiodoplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with bis(hydroxypheny)ethylenediamines); 58520-46-0P Role: PREP (Preparation) (formation and and ether cleavage or reaction of, with methoxybenzaldehyde); 149949-31-5P; 149949-32-6P; 149949-33-7P; 149949-34-8P; 149949-35-9P; 149949-36-0P; 149949-37-1P; 149949-38-2P Role: RCT (Reactant), PREP (Preparation), RACT (Reactant or reagent) (formation and hydrolysis of); 459-60-9 (4-Fluoroanisole) Role: RCT (Reactant), RACT (Reactant or reagent) (formylation and chlorination of); 452-09-5; 452-10-8 (2,4-Difluoroanisole) Role: RCT (Reactant), RACT (Reactant or reagent) (formylation of); 58519-82-7 Role: RCT (Reactant), RACT (Reactant or reagent) (hydrolysis of); 150390-74-2P; 150412-97-8P; 150520-05-1P; 150520-06-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and anti-mammary tumor activity of); 150390-79-7P; 150412-98-9P; 150447-55-5P; 150520-05-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and anti-mammary tumor activity of racemic); 149949-25-7P; 149949-39-3P; 149949-40-6P; 149949-41-7P; 149949-42-8P; 149949-43-9P; 149949-44-0P; 149949-45-1P; 149949-46-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage of); 149949-26-8P; 149949-27-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrolysis of); 56962-14-2P (2,6-Dichloro-3-hydroxybenzaldehyde) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and methylation of); 150447-54-4P; 150447-57-7P; 150447-58-8P; 150447-59-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and reaction of racemic, with sulfate); 58519-80-5P; 119386-71-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with halomethoxybenzaldehydes); 149949-17-7P; 149949-18-8P; 149949-19-9P; 149949-20-2P; 149949-21-3P; 149949-22-4P; 149949-23-5P; 149949-24-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with platinate iodo complex); 150390-73-1P; 150390-80-0P; 150390-81-1P; 150390-82-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with sulfate); 6505-37-9 (2,6-Dichloro-3-methoxybenzaldehyde); 112641-64-2 (2-Chloro-6-fluoro-5-methoxybenzaldehyde); 149949-29-1 (2-Chloro-6-fluoro-3-methoxybenzaldehyde); 149949-30-4 (2,6-Diuoro-3-methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with bis(methoxyphenyl)ethylenediamines); 135-02-4 (2-Methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with diphenylethylenediamines) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Neoplasm inhibitors (platinum bis(hydroxypheny)ethylenediamine complexes, for mammary tumors) Amines Role: SPN (Synthetic preparation), PREP (Preparation) (di-, platinum complexes, prepn. and anti-mammary tumor activity of) antitumor activity platinum hydroxyphenylethylenediamine complex amine hydroxyphenylethylenedi platinum complex | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 17697 |
Zusammenfassung
The synthesis and structural characterization of mammary tumor-inhibiting, diastereomeric [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes with 2,6-Cl2, 2-F, 6-Cl, 2-Cl, 6-F and 2,6-F2 substituents (1-PtSO4 to 4-PtSO4) are described. L are synthesized by stereoselective meso-meso and D,L-D,L diaza-Cope-rearrangement reactions and coordinated to Pt(II) with K2PtI4 to give ...
Zusammenfassung
The synthesis and structural characterization of mammary tumor-inhibiting, diastereomeric [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes with 2,6-Cl2, 2-F, 6-Cl, 2-Cl, 6-F and 2,6-F2 substituents (1-PtSO4 to 4-PtSO4) are described. L are synthesized by stereoselective meso-meso and D,L-D,L diaza-Cope-rearrangement reactions and coordinated to Pt(II) with K2PtI4 to give PtLI2. The subsequent reaction with Ag2SO4 leads to PtLSO4. They were tested for their antitumor activities of the hormone-sensitive and-insensitive MXT mammary carcinoma implanted in mice (MXT-MC, ER+ and MXT-MC, ER-). Complexes with F atoms in the neighborhood of the 3-hydroxy group showed strong inhibitory effects on the MXT-MC, ER+. The best effects were found for the diastereomeric 2,6-F2-substituent-complexes. These complexes are strongly active both on the MXT-MC, ER+ and the MXT-MC, ER- and cause no estrogenic side effects.
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