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The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes

Gust, Ronald ; Gelbcke, Michael ; Angermaier, Bernhard ; Bachmann, Helmut ; Krauser, Rudolf ; Schönenberger, Helmut



Abstract

The syntheses of enantiomeric threo- and erythro-1,2-diamino-1-phenylpropanes (Ph/Me) and of racemic 1,2-diaminophenylethane (Ph/H) are described. These diamines and related N2-methyl- and N1,N2-dimethyl-1,2-diamino-1-phenylpropanes were transformed into dichloroplatinum(II) complexes I [R1 = R2 = R3 = H (Ph/H-PtCl2); R1 = Me, R2 = R3 = Me (Ph/Me-PtCl2); R1 = R3 = Me, R2 = H (Ph/Me-Me-PtCl2); R1 ...

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