Gust, Ronald, Krauser, Rudolf, Schmid, Beate und Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), S. 27-35.
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Zusammenfassung
The synthesis of the diastereomeric [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes, rac- and meso-4F-Pt(X) [X = oxalato (Ox), malonato (Mal), hydroxymalonato (OHMal), phenylmalonato (PhMal), tetrahydro-4H-pyran-4,4-dicarboxylato (Thpdc)], the evaluation of their structure, water soly., resistance against attack by nucleophiles, and growth inhibiting properties on ...
Bibliographische Daten exportieren
| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Datum: | 1998 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 128:162186 78-7 Inorganic Chemicals and Reactions 80-69-3 (Hydroxymalonic acid); 141-82-2 (Malonic acid); 144-62-7 (Oxalic acid); 2613-89-0 (Phenylmalonic acid); 5337-04-2 (Tetrahydro-4H-pyran-4,4-dicarboxylic acid); 184895-34-9; 185069-15-2 Role: RCT (Reactant), RACT (Reactant or reagent) (for prepn. of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes); 7681-11-0 (Potassium iodide) Role: PEP (Physical, engineering or chemical process), PROC (Process) (kinetics of nucleophilic substitution by I- of platinum fluorophenylethylenediamine dicarboxylato complexes); 202755-80-4P; 202755-81-5P; 202755-82-6P; 202755-83-7P; 202755-84-8P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn., water soly., and antitumor activity against human MCF-7 breast cancer); 202646-08-0P; 202646-09-1P; 202646-10-4P; 202646-11-5P; 202646-12-6P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn., water soly., antitumor activity against human MCF-7 breast cancer, and kinetics of nucleophilic substitution by I-) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer) | ||||
| Projekte: | SFB 234 | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Transition metal complexes Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (carboxylic acid, platinum prepn., water soly., and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Antitumor agents (mammary gland prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Mammary gland (neoplasm, inhibitors prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Substitution reaction kinetics (nucleophilic of platinum fluorophenylethylenediamine dicarboxylato complexes with iodide) Carboxylic acids Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (transition metal complexes, platinum prepn., water soly., and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Solubility (water soly. of platinum fluorophenylethylenediamine dicarboxylato complexes) fluorophenylethylenediamine dicarboxylato platinum complex prepn antitumor activity platinum fluorophenylethylenediamine dicarboxylato complex soly fluorophenylethylenediamine dicarboxylato platinum complex nucleophilic substitution kinetics fluorophenylethylenediamine dicarboxylatoplatinum complex | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Eingebracht am: | 09 Nov 2010 14:18 | ||||
| Zuletzt geändert: | 24 Mai 2018 12:18 | ||||
| Dokumenten-ID: | 17718 |
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