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Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes

Gust, Ronald ; Krauser, Rudolf ; Schmid, Beate ; Schönenberger, Helmut



Abstract

The synthesis of the diastereomeric [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes, rac- and meso-4F-Pt(X) [X = oxalato (Ox), malonato (Mal), hydroxymalonato (OHMal), phenylmalonato (PhMal), tetrahydro-4H-pyran-4,4-dicarboxylato (Thpdc)], the evaluation of their structure, water soly., resistance against attack by nucleophiles, and growth inhibiting properties on ...

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