Gust, Ronald, Faderl, Michael und Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), S. 647-654.
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Zusammenfassung
In the search for new anti-breast cancer compds. a series of diastereomeric aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes was tested on the hormone-sensitive MXT-M-3.2 breast cancer of the mouse. By simultaneous detn. of tumor and uterine wts. at the end of the expt. the authors obtained an insight into the mode of action. Changes in the uterine wts. ...
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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Datum: | 2000 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 135:40383 1-3 Pharmacology 126735-37-3; 128413-06-9; 128413-07-0; 128413-08-1; 128413-09-2; 128413-10-5; 128413-11-6; 128413-12-7; 128413-13-8; 128524-07-2; 128524-08-3; 128524-09-4; 128524-10-7; 128524-11-8; 128524-12-9; 128524-13-0; 128524-14-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), USES (Uses) ([Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer) | ||||
| Projekte: | SFB 234 | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | DNA formation ([Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Estrogens Role: BAC (Biological activity or effector, except adverse), BPR (Biological process), BSU (Biological study, unclassified), MFM (Metabolic formation), BIOL (Biological study), FORM (Formation, nonpreparative), PROC (Process) ([Aqua-1-(2,6-dic Structure-activity relationship (antitumor [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Antitumor agents (mammary gland [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Mammary gland (neoplasm, inhibitors [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) antitumor breast phenylethylenediamine platinum complex | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Eingebracht am: | 09 Nov 2010 14:14 | ||||
| Zuletzt geändert: | 08 Mrz 2017 08:28 | ||||
| Dokumenten-ID: | 17720 |
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