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[Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties

Gust, Ronald ; Faderl, Michael ; Schönenberger, Helmut



Abstract

In the search for new anti-breast cancer compds. a series of diastereomeric aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes was tested on the hormone-sensitive MXT-M-3.2 breast cancer of the mouse. By simultaneous detn. of tumor and uterine wts. at the end of the expt. the authors obtained an insight into the mode of action. Changes in the uterine wts. ...

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