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Genes optimized by evolution for accurate and fast translation encode in Archaea and Bacteria a broad and characteristic spectrum of protein functions

URN to cite this document:
urn:nbn:de:bvb:355-epub-179858
DOI to cite this document:
10.5283/epub.17985
von Mandach, Conrad ; Merkl, Rainer
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License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 15 Nov 2010 14:01


Abstract

BACKGROUND: In many microbial genomes, a strong preference for a small number of codons can be observed in genes whose products are needed by the cell in large quantities. This codon usage bias (CUB) improves translational accuracy and speed and is one of several factors optimizing cell growth. Whereas CUB and the overrepresentation of individual proteins have been studied in detail, it is still ...

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