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Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y

Wiedemann, Sonja M. ; Mildner, Silke N. ; Bönisch, Clemens ; Israel, Lars ; Maiser, Andreas ; Matheisl, Sarah ; Straub, Tobias ; Merkl, Rainer ; Leonhardt, Heinrich ; Kremmer, Elisabeth ; Schermelleh, Lothar ; Hake, Sandra B.



Abstract

Nucleosomal incorporation of specialized histone variants is an important mechanism to generate different functional chromatin states. Here, we describe the identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. Their messenger RNAs are found in certain human cell lines, in addition to several normal and malignant human tissues. In keeping with their ...

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