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Abstract
The prepn. of antitumor pharmaceuticals contg. (1,2-diphenylethylenediamine) Pt(II)-complexes I (where R1, R2, R3, R4, same or different, are: H, OH, C1-6 alkoxy, substituted C2-6 alkanoyloxy or C3-6 alkenoxyloxy, of which at least one R group is not H; X = physiol. tolerable anion) is given. Thus, (+)-dichloro-[1,2-bis-(4-hydroxyphenyl)ethylenediamine]platinum(II) (II) [91326-62-4], dissolved in ...
Abstract
The prepn. of antitumor pharmaceuticals contg. (1,2-diphenylethylenediamine) Pt(II)-complexes I (where R1, R2, R3, R4, same or different, are: H, OH, C1-6 alkoxy, substituted C2-6 alkanoyloxy or C3-6 alkenoxyloxy, of which at least one R group is not H; X = physiol. tolerable anion) is given. Thus, (+)-dichloro-[1,2-bis-(4-hydroxyphenyl)ethylenediamine]platinum(II) (II) [91326-62-4], dissolved in H2O with a pH of 2.5-3.5 after sterilization filtration, is an effective injectable soln. II was prepd. from K2PtCl4 and (+)-1,2-bis(4-hydroxyphenyl)ethylenediamine-2HBr [91548-22-0].
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