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5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound

Schneider, Martin R. ; von Angerer, Erwin ; Schönenberger, Helmut


The title indene I was prepd. by cyclization of hexanediol II. I has a marked affinity to the cytoplasmic estrogen receptor and only weak uterotrophic, but antiuterotrophic properties in the mouse uterine wt. bioassay. I inhibits the growth of the DMBA-induced, hormone-dependent mammary carcinoma of the rat.

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