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Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I. The antibacterial effect

Laske, Reiner ; Schönenberger, Helmut ; Holler, Eggehard


Amino acid antagonists with proven or potentially inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against Escherichia coli B. The compds. 4- and 6-fluorotryptophan, 5-methyltryptophan, selenocysteine, and beta -(2-thienyl)alanine gave strong growth inhibition in minimal medium, which disappeared after the addn. of structurally related natural ...


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