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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Archiv der Pharmazie | ||||
| Publisher: | Wiley | ||||
| Volume: | 322 | ||||
| Number of Issue or Book Chapter: | 12 | ||||
| Page Range: | pp. 847-852 | ||||
| Date: | 1989 | ||||
| Additional Information (public): | CAN 112:135860 10-5 Microbial Biochemistry 9028-02-8 (Aminoacyl-tRNA synthetase) Role: BIOL (Biological study) (amino acid antagonist targeting for, antibacterial activity of); 52-90-4 (Cysteine); 56-40-6 (Glycine); 56-41-7 (L-Alanine); 56-45-1 (Serine); 56-84-8 (Aspartic acid); 56-85-9 (Glutamine); 56-86-0 (Glutamic acid); 56-87-1 (Lysine); 60-18-4 (Tyrosine); 61-90-5 (Leucine); 63-68-3 (Methionine); 63-91-2 (L-Phenylalanine); 70-47-3 (Asparagine); 71-00-1 (Histidine); 72-18-4 (L-Valine); 72-19-5 (Threonine); 73-22-3 (Tryptophan); 73-32-5 (Isoleucine); 74-79-3 (L-Arginine); 147-85-3 (Proline) Role: BIOL (Biological study) (antagonist of, targeting for aminoacyl-tRNA synthetases, antibacterial activity of); 50-67-9 (5-Hydroxytryptamine); 51-61-6 (3-Hydroxytyramine); 51-65-0 (DL-4-Fluorophenylalanine); 51-67-2 (Tyramine); 56-12-2; 60-23-1 (Cysteamine); 61-54-1 (Tryptamine); 62-57-7 (2-Aminoisobutyric acid); 63-84-3 (DL-3,4-Dihydroxyphenylalanine); 64-12-0 (DL-p-Chloroamphetamine); 67-21-0 (DL-Ethionine); 70-78-0 (3-Iodo-L-tyrosine); 103-01-5 (N-Phenylglycine); 104-63-2 (N-Benzylethanolamine); 153-44-6 (beta -Methyl-DL-tryptophan); 153-91-3 (alpha -Methyl-DL-tryptophan); 299-26-3; 403-90-7 (DL-3-Fluorotyrosine); 405-39-0; 443-80-1; 456-88-2 (DL-3-Fluorophenylalanine); 500-44-7; 526-31-8; 536-33-4 (Ethionamide); 541-48-0 (DL-3-Aminobutyric acid); 543-38-4; 552-85-2; 587-20-2 (alpha -Methylhistidine); 621-44-3 (3-Nitro-L-tyrosine); 671-42-1 (DL-alpha -Amino-e-caprolactam); 687-51-4 (L-Leucinamide); 760-78-1 (DL-Norvaline); 951-55-3 (5-Methyl-DL-tryptophan); 979-92-0 (S-Adenosyl-L-homocysteine); 1113-41-3; 1132-26-9 (alpha -Methyl-DL-phenylalanine); 1138-80-3; 1149-26-4; 1464-42-2 (Seleno-DL-methionine); 1483-07-4; 1955-68-6; 2021-58-1 (beta -2-Thienyl-DL-alanine); 2133-34-8 (L-Azetidine-2-carboxylic acid); 2260-12-0 (beta -Methyl-DL-phenylalanine); 2280-42-4 (DL-beta -Hydroxynorvaline); 2629-55-2 (DL-2-Fluorophenylalanine); 2697-61-2 (Selenocystamine); 2731-73-9 (L-beta -Chloroalanine); 2749-07-7 (alpha -Methyl-DL-methionine); 2792-72-5; 2799-07-7; 2897-21-4 (DL-Selenocystine); 2899-37-8 (L-Methioninol); 2935-35-5 (L-alpha -Phenylglycine); 2936-69-8 (L-4-Thialysine); 3182-95-4 (L-Phenylalaninol); 3251-08-9; 3395-35-5 (DL-3,4-Dehydroproline); 3647-71-0 (N-Benzyl-2-phenylethylamine); 4144-02-9 (L-O-Methylthreonine); 4350-07-6 (D-5-Hydroxytryptophan); 4383-81-7; 4510-08-1 (L-Methioninamide); 4746-36-5 (DL-4-Azaleucine); 4836-52-6 (L-Histidinol); 5034-68-4 (L-Tyrosinol); 6000-08-4; 6232-19-5 (beta -Cyano-L-alanine); 6645-45-0; 6829-40-9 (Aminomalonic acid diethyl ester); 7303-50-6 (DL-7-Azatryptophan); 7533-40-6 (L-Leucinol); 7695-56-9 (DL-Threo-beta -Phenylserine); 7730-20-3 (DL-6-Fluorotryptophan); 10065-72-2 (L-Alanine methyl ester); 10367-17-6; 13004-62-1; 14954-40-6; 16063-80-2; 16748-73-5 (L-Aspartic acid diamide); 17332-70-6 (7-Methyl-DL-tryptophan); 17463-43-3 (3,3,3-Trifluoro-DL-alanine); 17480-69-2 (N-Benzyl-D-amphetamine); 17781-05-4; 18625-03-1; 19461-04-2; 23220-52-2 (Meso-2,3-Diaminosuccinic acid); 24629-25-2 (L-Isoleucinol); 25631-05-4 (DL-4-Fluorotryptophan); 26340-83-0; 26988-72-7 (1-Methyl-DL-tryptophan); 28057-52-5 (L-Isoasparagine); 28143-91-1; 34592-47-7; 34985-37-0; 40172-05-2; 55779-32-3; 57601-68-0; 57734-57-3 (2-Aminomethylpyrrolidine); 60046-47-1; 65934-95-4; 75543-73-6; 80300-21-6; 91531-30-5; 108321-88-6; 123760-55-4; 124081-74-9; 125293-76-7; 125293-77-8; 125293-81-4; 125293-82-5; 125293-86-9; 125356-75-4; 125708-39-6; 125729-28-4; 125762-00-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (as amino acid antagonist targeting for aminoacyl-tRNA synthetase, antibacterial activity of) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Identification Number: |
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| Keywords: | Antibiotics (amino acid antagonists, targeting for aminoacyl-tRNA synthetases) Amino acids Role: BIOL (Biological study) (antagonist of, targeting for aminoacyl-tRNA synthetases, antibacterial activity of) Escherichia coli (inhibition of, by amino acid antagonist targeting for aminoacyl-tRNA synthetases) Molecular structure-biological activity relationship (bactericidal, of amino acid antagonists targeting for aminoacyl-tRNA synthetases) aminoacyl tRNA synthetase inhibitor antibacterial | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Item ID: | 18120 |
Abstract
Amino acid antagonists with proven or potentially inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against Escherichia coli B. The compds. 4- and 6-fluorotryptophan, 5-methyltryptophan, selenocysteine, and beta -(2-thienyl)alanine gave strong growth inhibition in minimal medium, which disappeared after the addn. of structurally related natural ...
Abstract
Amino acid antagonists with proven or potentially inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against Escherichia coli B. The compds. 4- and 6-fluorotryptophan, 5-methyltryptophan, selenocysteine, and beta -(2-thienyl)alanine gave strong growth inhibition in minimal medium, which disappeared after the addn. of structurally related natural amino acids or in an enriched broth. The inhibitory effect on aminoacyl-tRNA synthetases and the minimal inhibitory concn. for growth inhibition in minimal medium could not be correlated.
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