The separation of N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamine dihydrochloride into its meso and racemic forms by Craig's partition method

Zusammenfassung

The title compd. (285 mg., m. 185-220 Deg) was put through a 24-tube Craig app. using the solvent system 28:12:40 2% sq. HClMeOH-CHCl3, which gave a vol. ratio of the phases of 1.6. Most of component A (106 mg., m. 174-6 Deg) remained in the first 2 tubes; most of component B (168 mg., m. 214-16 Deg) was found in tubes 5 to 17 with a max. concn. in tube 11. By analogy with other stereoisomeric alpha ,alpha '-diphenylethylenediamines, it is concluded that A is racemic and B is meso.