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Separation of organic bases by Craig partition. V. Synthesis and separation of aminoacylephedrine isomers, a new class of local anesthetics

Schönenberger, Helmut ; Brinkmann, R. ; Bamann, E.


cf. CA 61, 2737g. N, N-Dimethylalanine (I) and N,N-dimethylphenylalanine (II) were condensed by the mixed anhydride method with amphetamine (III), ephedrine (IV), and y-ephedrine (V) to give RCH2CH(NMe2)CONR1-CHMeCHPhR2 (VI) (R = H or Ph, R1 = H or Me, R2 = H or OH). By Craig partition in CHCl3-MeOH-aq. buffer systems, individual isomers were sepd. from the diastereoisomeric mixts. obtained from ...


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