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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Arzneimittel-Forschung = Drug research | ||||
| Verlag: | Editio-Cantor-Verlag | ||||
| Band: | 13 | ||||
| Seitenbereich: | S. 936-939 | ||||
| Datum: | 1963 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 60:92729 62 Microbial Biochemistry 614-17-5; 14180-11-1; 14216-34-3; 90887-50-6 (Derived from data in the 7th Collective Formula Index (1962-1966); 55-21-0 (Benzamide); 87-17-2 (Salicylanilide); 89-55-4 (Salicylic acid, 5-bromo-); 613-93-4 (Benzamide, N-methyl-); 619-57-8 (Benzamide, p-hydroxy-); 1697-18-3 (Salicylanilide, 2'-chloro-); 2280-99-1 (p-Anisamide, N-butyl-); 2627-77-2 (Salicylanilide, 4'-bromo-); 3400-22-4 (p-Anisamide, N-methyl-); 3679-63-8 (Salicylanilide, 4'-chloro-); 3679-68-3 (Benzanilide, 4'-chloro-4-hydroxy-); 6137-53-7 (Salicylanilide, 2',5'-dichloro-); 7403-41-0 (p-Anisamide, N-ethyl-); 7464-43-9 (p-Anisamide, N-propyl-); 7464-44-0 (p-Anisamide, N-isopropyl-); 7465-88-5 (p-Anisanilide); 7595-61-1 (p-Anisanilide, 4'-chloro-); 10546-70-0 (Benzamide, N-propyl-); 13410-91-8 (Salicylanilide, 2',3'-dichloro-); 14121-97-2 (Benzanilide, 4-hydroxy-); 24448-71-3 (Salicylanilide, 3'-chloro-); 27519-68-2 (Benzamide, p-hydroxy-N-propyl-); 27522-79-8 (Benzamide, N-ethyl-p-hydroxy-); 27559-45-1 (Benzanilide, 3-hydroxy-); 36965-04-5 (Benzanilide, 4'-chloro-4-hydroxy-, acetate); 37183-28-1 (Salicylanilide, 2',4'-dichloro-); 39114-64-2 (Benzamide, N-cyclohexyl-p-hydroxy-); 52189-56-7 (Benzanilide, 4'-bromo-4-hydroxy-); 58748-19-9 (Benzamide, ethoxy-); 60696-49-3 (Benzamide, N-butyl-p-hydroxy-); 62639-20-7 (Benzanilide, 2'-chloro-4-hydroxy-); 73544-81-7 (Benzanilide, 3'-chloro-3-hydroxy-); 73544-82-8 (Benzanilide, 4'-chloro-3-hydroxy-); 83191-67-7 (Benzamide, p-hydroxy-N-isopropyl-); 92044-46-7 (Benzanilide, 2'-chloro-3-hydroxy-); 92044-47-8 (Benzanilide, 3'-chloro-4-hydroxy-); 92433-68-6 (Benzanilide, 2'-chloro-4-hydroxy-, acetate); 92433-69-7 (Benzanilide, 3'-chloro-4-hydroxy-, acetate); 92433-81-3 (Carbonic acid, methyl ester, ester with 2'-chloro-4-hydroxybenzanilide); 92433-81-3 (Benzanilide, 2'-chloro-4-hydroxy-, methyl carbonate); 92433-82-4 (Benzanilide, 4'-chloro-4-hydroxy-, methyl carbonate); 92433-82-4 (Carbonic acid, methyl ester, ester with 4'-chloro-4-hydroxybenzanilide); 92905-58-3 (Benzanilide, 4'-bromo-3-hydroxy-); 97027-63-9 (Benzanilide, 2',3'-dichloro-3-hydroxy-); 97027-64-0 (Benzanilide, 2',4'-dichloro-3-hydroxy-); 97027-66-2 (Benzanilide, 2',5'-dichloro-3-hydroxy-) (bactericidal action of) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Bactericides, Disinfectants and Antiseptics (hydroxybenzamide derivs. as) Staphylococcus (aureus (includes albus and citreus), hydroxybenzamide deriv. effect on) Benzoic acid Benzoic acid Salicylic acid (bactericidal action of) | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe | ||||
| Dokumenten-ID: | 18165 |
Zusammenfassung
cf. CA 59, 2070e. Of the hydroxybenzamides tested, the o-hydroxybenzanilides with 1 or 2 halogen atoms in the anilide ring exhibit the highest activity against Staphylococcus aureus. Highest activity was shown by the 4-bromoanilide and 2,4-dichloroanilide. The fact that the phenolic hydroxyl group has a marked influence on bacteriostatic properties was demonstrated by complete loss of such ...
Zusammenfassung
cf. CA 59, 2070e. Of the hydroxybenzamides tested, the o-hydroxybenzanilides with 1 or 2 halogen atoms in the anilide ring exhibit the highest activity against Staphylococcus aureus. Highest activity was shown by the 4-bromoanilide and 2,4-dichloroanilide. The fact that the phenolic hydroxyl group has a marked influence on bacteriostatic properties was demonstrated by complete loss of such activity when shifting this group to the meta position. When, on the other hand, the hydroxyl substituent is shifted to the para position, the antibacterial effect was much enhanced, provided 2 Cl atoms were present in the aniline ring (p-hydroxybenz-2,3-dichloroanilide and p-hydroxybenz-2,4-dichloroanilide). An influence of halogen position on bacteriostatic activity is slightly noticeable in monohalogen derivs., but is very pronounced in dihalogenated hydroxybenzanilides. The 2,4-position proved to be the most favorable configuration.
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