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Chemical constitution and bacteriostatic activity of isomeric hydroxybenzamides. II. Antimycotic substances

Schönenberger, Helmut ; Holzheu-Eckardt, Juergen ; Bamann, Eugen ; Mehnert, Brigitte



Abstract

cf. CA 59, 2070e. Of the hydroxybenzamides tested, the o-hydroxybenzanilides with 1 or 2 halogen atoms in the anilide ring exhibit the highest activity against Staphylococcus aureus. Highest activity was shown by the 4-bromoanilide and 2,4-dichloroanilide. The fact that the phenolic hydroxyl group has a marked influence on bacteriostatic properties was demonstrated by complete loss of such ...

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