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Regulation and localization of TOB and IFR1 in differentiating red cells

Steiner, Simone K. ; Baumann, Rosemarie ; Dragon, Stefanie


In differentiating red blood cells (RBCs) of the chick embryo, the synthesis of carbonic anhydrase (CAII) and pyrimidine 5'-nucleotidase (P5N-I) is triggered by the hypoxic mediators norepinephrine and adenosine via receptor-mediated cAMP formation. The process is accompanied by the induction of IFR1 and TOB which are putative regulators of transcription or translation in different cell types. ...


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