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Effect of high altitude and in vivo adenosine/-adrenergic receptor blockade on ATP and 2,3BPG concentrations in red blood cells of avian embryos

Dragon, Stefanie ; Carey, C. ; Martin, K. ; Baumann, Rosemarie



Abstract

In chick embryos, developmental changes of the blood oxygen tension control hemoglobin (Hb) oxygen affinity via modulation of ATP and 2, 3BPG concentrations in red blood cells. Hypoxia, which is a normal developmental condition for late chick embryos, causes a decrease of the red cell ATP concentration (and increase of red cell oxygen affinity) as well as activation of 2,3BPG synthesis via cyclic ...

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