The influence of cold shock proteins on transcription and translation studied in cell-free model systems

DOI to cite this document:: 10.5283/epub.1878

Hofweber, Roland ; Horn, Gudrun ; Langmann, Thomas ; Balbach, Jochen ; Kremer, Werner ; Schmitz, Gerd ; Kalbitzer, Hans-Robert

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Date of publication of this fulltext: 05 Aug 2009 13:34

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Abstract

Cold shock proteins (CSPs) form a family of highly conserved bacterial proteins capable of single-stranded nucleic acid binding. They are suggested to act as RNA chaperones during cold shock inhibiting the formation of RNA secondary structures, which are unfavourable for transcription and translation. To test this commonly accepted theory, isolated CSPs from a mesophilic, thermophilic and a ...