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Separation of water artefacts in 2D NOESY protein spectra using congruent matrix pencils

Stadlthanner, Kurt ; Tomé, A. M. ; Theis, Fabian ; Lang, Elmar ; Gronwald, Wolfram ; Kalbitzer, Hans-Robert



Abstract

Multidimensional proton nuclear magnetic resonance spectra of biomolecules dissolved in aqueous solutions are usually contaminated by an intense water artifact. We discuss the application of a generalized eigenvalue decomposition (GEVD) method using a matrix pencil to solve the blind source separation (BSS) problem of removing the intense solvent peak and related artifacts. The method explores ...

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