Palladium and copper mediated N-aryl bond formation reactions for the synthesis of biological active compounds

Fischer, Carolin and König, Burkhard (2011) Palladium and copper mediated N-aryl bond formation reactions for the synthesis of biological active compounds. Beilstein Journal of Organic Chemistry (7), pp. 59-74.

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Abstract

N-Arylated aliphatic and aromatic amines are important substituents in many biologically active compounds. In the last few years, transition-metal-mediated N-aryl bond formation has become a standard procedure for the introduction of amines into aromatic systems. While N-arylation of simple aromatic halides by simple amines works with many of the described methods in high yield, the reactions may ...

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