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Direct evidence of endothelial injury during cardiopulmonary bypass by demonstration of circulating endothelial cells

Schmid, Franz-Xaver ; Floerchinger, Bernhard ; Vudattu, Nalini Kumar ; Eissner, Günther ; Haubitz, Marion ; Holler, Ernst ; Andreesen, Reinhard ; Birnbaum, Dietrich E.



Abstract

Endothelial activation is considered a key process in the development of a whole body inflammatory response secondary to cardiopulmonary bypass (CPB). Increased levels of a multitude of soluble mediators have been described as being released during and after cardiac surgery. Circulating endothelial cells have recently been established as a novel marker of endothelial damage in a variety of ...

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