Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1942

Catto, James W. F. ; Hartmann, Arndt ; Stoehr, Robert ; Bolderson, Emma ; Rehman, Ishtiaq ; Rosario, Derek J. ; Hamdy, Freddie C. ; Meuth, Mark

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:35

Alternative Links zum Volltext:Pubmed DOI Verlag

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PURPOSE: UC is a disease of the entire urothelium, characterized by multiplicity and multifocality. The clonal relationship among multiple UCs has implications regarding adjuvant chemotherapy. It has been investigated in studies of chromosomal alteration and single gene mutation. However, these genetic changes can occur in unrelated tumors under similar carcinogenic selection pressures. Tumors ...