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Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder

DOI to cite this document:
10.5283/epub.1945
van Oers, Johanna M. M. ; Adam, Christoph ; Denzinger, Stefan ; Stoehr, Robert ; Bertz, Simone ; Zaak, Dirk ; Stief, Christian ; Hofstaedter, Ferdinand ; Zwarthoff, Ellen C. ; van der Kwast, Theodorus H. ; Knuechel, Ruth ; Hartmann, Arndt
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Date of publication of this fulltext: 22 Jun 2010 09:35


Abstract

Flat urothelial hyperplasias (FUHs) in patients with papillary bladder tumours frequently show deletions of chromosome 9, suggesting that FUH could be the first neoplastic step in the development of papillary bladder cancer. FGFR3 mutations are frequent in non-invasive papillary tumours with low risk of progression. Our aim was to investigate the frequency of FGFR3 mutations and deletions of ...

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