Reduced responsiveness of adenylate cyclase to forskolin in human lymphoma cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-196366
DOI to cite this document:: 10.5283/epub.19636

Hallek, M. ; Kampfrath, T. ; Haen, Ekkehard ; Göhly, U. ; Emmerich, B. ; Remien, J.

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Date of publication of this fulltext: 18 Feb 2011 10:22

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Abstract

The beta 2-adrenergic transmembrane signal transduction was investigated in malignant B-cells from 15 patients with low grade non-Hodgkin's lymphoma as compared with normal lymphocytes of seven healthy adults. The number of beta 2-adrenoceptors and the response of adenylate cyclase (AC) to isoproterenol were slightly decreased in lymphoma cells. The responsiveness of AC to forskolin was 8-fold ...