Bedeutung der Chronopharmakologie für die Onkologie (= The significance of chronopharmacology for oncology)

URN to cite this document:: urn:nbn:de:bvb:355-epub-196414
DOI to cite this document:: 10.5283/epub.19641

Hallek, M. ; Lévi, F. ; Haen, Ekkehard ; Emmerich, B.

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Date of publication of this fulltext: 11 Mar 2011 06:32

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Abstract

Many physiological variables in hemato-oncology, e.g. the function of liver and kidney and hematopoiesis, show circadian changes. Consequently, the metabolism, elimination and myelotoxicity of cytostatic drugs are subjected to circadian variations in animal and man. Moreover, preliminary clinical data suggest that an optimal circadian timing may even increase the efficacy of anticancer ...