Circannual variation in the expression of beta 2-adrenoceptors on human peripheral mononuclear leukocytes (MNLs)

URN to cite this document:

urn:nbn:de:bvb:355-epub-196432 Copy

DOI to cite this document:

10.5283/epub.19643 Copy

Haen, Ekkehard ; Langenmayer, I. ; Pangerl, A. ; Liebl, B. ; Remien, J.

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Date of publication of this fulltext: 18 Feb 2011 09:54

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Details

Item type:	Article
Journal or Publication Title:	Klinische Wochenschrift / Journal of molecular medicine
Publisher:	Springer
Volume:	66
Number of Issue or Book Chapter:	13
Page Range:	pp. 579-582
Date:	1988
Institutions:	Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:	Value Type 2850403 PubMed ID 10.1007/BF01720832 DOI
Classification:	Notation Type Adult MESH Asthma/blood MESH Circadian Rhythm MESH Humans MESH Hypertension/blood MESH Leukocytes, Mononuclear/metabolism MESH Male MESH Periodicity MESH Radioligand Assay MESH Receptors, Adrenergic, beta/metabolism MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Unknown
Created at the University of Regensburg:	Unknown
Item ID:	19643

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Abstract

Peripheral mononuclear leukocytes (MNLs) are widely used as a tissue model in studies of beta-adrenoceptor disturbances in hypertension and asthmatic diseases. The beta 2-adrenoceptor density (Bmax), however, depends not only on the gender of the person under study and on the time of day the blood specimens are obtained. Evidence is now reported for a circannual variation in the expression of ...

Abstract

Peripheral mononuclear leukocytes (MNLs) are widely used as a tissue model in studies of beta-adrenoceptor disturbances in hypertension and asthmatic diseases. The beta 2-adrenoceptor density (Bmax), however, depends not only on the gender of the person under study and on the time of day the blood specimens are obtained. Evidence is now reported for a circannual variation in the expression of beta 2-adrenoceptor sites on peripheral MNLs. In male volunteers the 24-h mean was found to be highest in the men studied in April/May (1135 +/- 10 sites/cell) and decreased to 891 +/- 16 sites/cell in August and to 712 +r90 sites/cell in December (means +/- SE, P less than 0.01 April/May compared to December). Concomitantly the circadian amplitude increased from 17.3% +/- 6.4% of 24-h mean in April/May to 28.2% +/- 1.4% of 24-h mean in August and to 34.2% +/- 4.2% of 24-h mean in December (means +/- SE, P less than 0.05, April/May compared to December). The circadian acrophase remained constant (190 degrees +/- 30 degrees equivalent to 12 h 40 min +/- 2 h 00 min, means +/- SE).

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