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Über die Bedeutung der Applikationsgeschwindigkeit für die pharmakokinetischen Parameter von Azlocillin und Mezlocillin (=The effect of infusion rate on pharmacokinetic parameters of azlocillin and mezlocillin)

URN to cite this document:
urn:nbn:de:bvb:355-epub-196489
Haen, Ekkehard ; Remien, J. ; Richter, E. ; Frank, U. ; Adam, D.
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Date of publication of this fulltext: 17 Mar 2011 08:02


Abstract

Azlocillin (Securopen) and mezlocillin (Baypen) were given to 3 healthy subjects as intravenous infusion. The dose of 4 g was administered to each person within 5, 15, and 30 min in a randomized crossover design. Using HPLC the unchanged penicillin antibiotics were determined quantitatively, their metabolites were assessed qualitatively. The same specimens were also studied by means of a bioassay ...

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