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Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells

Roesch, Alexander ; Becker, Bernd ; Schneider-Brachert, Wulf ; Hagen, Ilja ; Landthaler, Michael ; Vogt, Thomas
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Date of publication of this fulltext: 05 Aug 2009 13:35


Abstract

The loss of cell cycle control in malignant melanomas is thought to be due to a lack of retinoblastoma protein (pRb) activity. We have recently reported a progressive deficiency of the retinoblastoma-binding protein 2-homolog 1 (RBP2-H1) in advanced and metastatic melanomas in vivo, suggesting a role of RBP2-H1 in loss of pRb-mediated control. Therefore, in this study, we re-established the ...

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