Five-Year Follow-up After Late Conversion From Calcineurin Inhibitors to Sirolimus in Patients With Chronic Renal Allograft Dysfunction

DOI to cite this document:: 10.5283/epub.1975

Krüger, Bernd ; Fischereder, Michael ; Jauch, Karl W. ; Graeb, Christian ; Hoffmann, Ute ; Böger, Carsten A. ; Banas, Bernhard ; Obed, Aiman ; Schlitt, Hans-Jürgen ; Krämer, Bernhard K.

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Date of publication of this fulltext: 05 Aug 2009 13:35

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Abstract

BACKGROUND: Chronic allograft nephropathy (CAN) is, among others, caused by nephrotoxic side effects of calcineurin inhibitors (CNI), which are to date still the mainstay of immunosuppressive therapy. Sirolimus (SIR), an immunosuppressive compound without effects on glomerular perfusion, has been used in CNI-sparing immunosuppressive protocols. We report the 5-year follow-up of a prospective, ...