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Influence of the cholinergic agonist RS 86 on normal sleep: sex and age effects

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Riemann, D. ; Joy, D. ; Höchli, D. ; Lauer, C. ; Zulley, Jürgen ; Berger, M.
Date of publication of this fulltext: 01 Mar 2011 07:11


In 36 healthy control subjects (21 females, 15 males; age range 18-65 years; mean age 41.8 years, SD 15.6 years), a bedtime dose of 1.5 mg RS 86, an orally acting cholinergic agonist, shortened rapid eye movement (REM) latency, increased REM sleep, and decreased slow-wave sleep. Six of the subjects (greater than 40 years old) even displayed sleep-onset REM periods after the drug. Results of the ...


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