Abstract
Pyrene labelled Zn2+-cyclen 1 and bis-Zn2+-bis-cyclen 2 complexes were synthesized. The reversible
coordination at physiological pH of Zn2+-cyclens to phosphate anions and to imide moieties, as present
in thymine and uracil nucleotides, is well known. In the presence of analytes bearing a phosphate and
an imide or two phosphate groups the formation of a ternary complex consisting of two ...
Abstract
Pyrene labelled Zn2+-cyclen 1 and bis-Zn2+-bis-cyclen 2 complexes were synthesized. The reversible
coordination at physiological pH of Zn2+-cyclens to phosphate anions and to imide moieties, as present
in thymine and uracil nucleotides, is well known. In the presence of analytes bearing a phosphate and
an imide or two phosphate groups the formation of a ternary complex consisting of two pyrene-labelled
metal complexes and the analyte molecule, is observed. The close proximity of the pyrene labels in the
complex induces pyrene excimer emission, which is observable by the unarmed eye. By this, the
presence of UMP, UDP, UTP and TTP in buffered aqueous solution is signalled, while other
nucleotides are not able to induce excimer emission. In the same way, Zn2+-cyclen-pyrene acts as
luminescent chemosensor for PPi and fructose-1,6-bisphosphate in aqueous buffer.
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