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The Effect of Trimipramine on Sleep in Patients with Major Depressive Disorder

URN to cite this document:
Wiegand, M. ; Berger, M. ; Zulley, Jürgen ; von Zerssen, D.
Date of publication of this fulltext: 04 Mar 2011 13:24


Antidepressants generally inhibit REM sleep. This effect is often considered to be a crucial feature of these drugs. Trimipramine, however, is a tricyclic antidepressant which does not inhibit REM sleep in rats (Khazan and Brown, 1970; Wassennan and Khazan, 1971). This result could be confirmed in man: Dunleavy et al. (1972) administered this drug to two healthy volunteers and found no alteration ...


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