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Delaney, Tetyana L. ; Zimin, Denys ; Rahm, Michael ; Weiss, Dieter ; Wolfbeis, Otto S. ; Mirsky, Vladimir M.

Capacitive Detection in Ultrathin Chemosensors Prepared by Molecularly Imprinted Grafting Photopolymerization

Delaney, Tetyana L., Zimin, Denys, Rahm, Michael, Weiss, Dieter , Wolfbeis, Otto S. and Mirsky, Vladimir M. (2007) Capacitive Detection in Ultrathin Chemosensors Prepared by Molecularly Imprinted Grafting Photopolymerization. Analytical Chemistry (including News & Features) 79 (8), pp. 3220-3225.

Date of publication of this fulltext: 18 Mar 2011 07:59
Article
DOI to cite this document: 10.5283/epub.20155


Abstract

The usual applications of capacitive detection in chemo- and biosensors are based on changes in effective thickness of insulating layers due to adsorption of analyte onto receptors. Ultrathin chemosensors based on molecularly imprinted polymerization enable a realization of another capacitive approach that exploits changes in electrical capacitance due to modification of the dielectric constant ...

The usual applications of capacitive detection in chemo- and biosensors are based on changes in effective thickness of insulating layers due to adsorption of analyte onto receptors. Ultrathin chemosensors based on molecularly imprinted polymerization enable a realization of another capacitive approach that exploits changes in electrical capacitance due to modification of the dielectric constant of the polymer. Such chemosensors were prepared by photografted molecularly imprinted polymerization on the surface of gold electrodes. An adsorbed layer of hydrophobic photoinitiator (benzophenone) provided grafted polymerization on the surface of the alkanethiol-modified gold electrode. The chemosensors were characterized by cyclic voltammetry, impedance spectroscopy, and scanning electron and atomic force microscopy. Binding of analyte was detected by measurements of electrical capacitance. The results indicate a decrease of the dielectric constant of the polymer layer due to analyte binding up to 20%.



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Details

Item typeArticle
Journal or Publication TitleAnalytical Chemistry (including News & Features)
Publisher:AMER CHEMICAL SOC
Place of Publication:WASHINGTON
Volume:79
Number of Issue or Book Chapter:8
Page Range:pp. 3220-3225
Date15 March 2007
InstitutionsPhysics > Institute of Experimental and Applied Physics > Chair Professor Weiss > Group Dieter Weiss
Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik
Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie
Identification Number
ValueType
10.1021/ac062143vDOI
KeywordsPHARMACEUTICAL ANALYSIS; PROTEIN IMMOBILIZATION; BIOMIMETIC SENSORS; GOLD ELECTRODES; POLYMERS; MONOLAYERS; ADSORPTION
Dewey Decimal Classification500 Science > 530 Physics
500 Science > 540 Chemistry & allied sciences
StatusPublished
RefereedUnknown
Created at the University of RegensburgUnknown
Item ID20155

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