Europium Tetracycline as a Luminescent Probe for Nucleoside Phosphates and Its Application to the Determination of Kinase Activity

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.20156

Schäferling, Michael ; Wolfbeis, Otto S.

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Veröffentlichungsdatum dieses Volltextes: 18 Mrz 2011 08:00

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Zusammenfassung

The determination of enzyme activities and the screening of enzyme regulators is a major task in clinical chemistry and drug development. A broad variety of enzymatic reactions is associated with the consumption of adenosine triphosphate (ATP), including, in particular, phosphorylation reactions catalyzed by kinases, formation of adenosine cyclic monophosphate (cAMP) by adenylate cyclases, and ...