Europium Tetracycline as a Luminescent Probe for Nucleoside Phosphates and Its Application to the Determination of Kinase Activity

DOI to cite this document:: 10.5283/epub.20156

Schäferling, Michael ; Wolfbeis, Otto S.

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Date of publication of this fulltext: 18 Mar 2011 08:00

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Abstract

The determination of enzyme activities and the screening of enzyme regulators is a major task in clinical chemistry and drug development. A broad variety of enzymatic reactions is associated with the consumption of adenosine triphosphate (ATP), including, in particular, phosphorylation reactions catalyzed by kinases, formation of adenosine cyclic monophosphate (cAMP) by adenylate cyclases, and ...