The Click Reaction in the Luminescent Probing of Metal Ions, and Its Implications on Biolabeling Techniques

Abstract

Copper concentrations at a click: The copper(I)-catalyzed Huisgen cycloaddition (the “click reaction”) enables micromolar concentrations of physiologically active Cu+ ions to be sensed through photonic energy transfer (ET, see scheme), and offers great potential in terms of labeling methods.