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The C-terminus of the γ2-chain but not β3-chain of laminin 332 is indirectly but indispensably necessary for integrin-mediated cell reactions.

Navdaev, A. ; Heitmann, V. ; de Santana Evangelista, K. ; Mörgelin, M. ; Wegener, Joachim ; Eble, J. A.


Using a recombinant mini-laminin-332, we showed that truncation of the three C-terminal amino acids of the gamma 2 chain, but not of the C-terminal amino acid of the 133 chain, completely abolished alpha 3 beta 1 integrin binding and its cellular functions, such as attachment and spreading. However, a synthetic peptide mimicking the gamma 2 chain C-terminus did not interfere with 0 l integrin ...


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