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MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.

Spiering, D. ; Schmolke, M. ; Ohnesorge, N. ; Schmidt, M. ; Goebeler, M. ; Wegener, Joachim ; Wixler, V. ; Ludwig, S.



Abstract

The formation of new blood vessels from pre-existing ones requires highly coordinated restructuring of endothelial cells (EC) and the surrounding extracellular matrix. Directed EC migration is a central step in this process and depends on cellular signaling cascades that initiate and control the structural rearrangements. On the basis of earlier findings that ERK5 deficiency in mouse EC results ...

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