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Nanotopography follows force in TGF-beta 1 stimulated epithelium.

Thölking, G. ; Reiss, B. ; Wegener, Joachim ; Oberleithner, H. ; Pavenstädt, H. ; Riethmüller, C.



Abstract

Inflammation and cellular fibrosis often imply an involvement of the cytokine TGF-beta 1. TGF-beta 1 induces epithelial-to-mesenchymal transdifferentiation (EMT), a term describing the loss of epithelium-specific function. Indicative for this process are an elongated cell shape parallel to stress fibre formation. Many signalling pathways of TGF-beta 1 have been discovered, but mechanical aspects ...

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